The diffraction peaks all corresponded to the product synthesized by Skobelev. Janina Dechnik, Christopher J. Inorganic Chemistry , 56 5 , Increasing numbers of apoptotic cells progressed from the early stage to the late stage resulting in either death or secondary necrosis under Fe-MIL at higher concentrations.
Nalaparaju, M. The Journal of Physical Chemistry C , 21 , Researchers have shown that MOFs containing iron species can be used as heterogeneous Fenton catalysts due to their attractive property of wide distribution of single iron sites and wide pH range application [ 14 ].
Increasing evidence suggests that the tumour microenvironment also plays critical roles in tumour progression and metastasis, and new strategies for synergistic tumour therapeutics target both tumour microenvironment and tumour cells 1. As the concentration of Fe-MIL increased from 3. Silica nanoparticles induced G1 phase arrest through upregulation of p53 and p21 in the rat embryonic ventricular myocardial cell line H9c2
These results are consistent with previous studies 61 , These catalysts, however, suffer from poor H2O2 utilization and low catalytic activity due to their limited exposed active sites [ 8 ].
The Journal of Physical Chemistry C , 23 , Previous studies demonstrated that ART exhibits anti-proliferation and anti-angiogenic activity as well as antitumour activity The Journal of Physical Chemistry C , 19 ,
Until now, the available toxicity information regarding MOFs have remained scarce and the contemporary use of MOFs for cancer treatment has been largely limited to serving as contrast agents for imaging techniques and carriers for drug delivery 28 , 29 , 30 , 31 ,
Berdonosova, Konstantin A. The Journal of Physical Chemistry C , 23 , This suggests that Fe-MIL may have a potential utility in the selective treatment of cancer cells. For instance, the toxicological effects of three different iron carboxylate MOFs, MIL88A fumarate , MIL88B tetramethylterephthalate and MIL trimesate , was examined by Horcajada and colleagues both in vitro and in vivo 34 , and all three showed no observable toxicity.
This effect was not due to cell death, because HUVECs did not show any morphological changes such as blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation or chromosomal DNA fragmentation. For instance, the toxicological effects of three different iron carboxylate MOFs, MIL88A fumarate , MIL88B tetramethylterephthalate and MIL trimesate , was examined by Horcajada and colleagues both in vitro and in vivo 34 , and all three showed no observable toxicity. The Journal of Physical Chemistry Letters , 5 16 , Wright, Philip L. Chen, A.
The adverse changes in mitochondrial function due to Fe-MIL, with possible association of intracellular reactive oxygen species ROS production, trigger the apoptosis process