Also, the body does not have the ability to produce S-adenosyl methionine which is known as "SAM" product. It results from the inhibition of DNA synthesis within red blood cell production. The most well-known type of this defect is "spina bifida," which can lead to many problems and issues, e. Purine has many important roles in cell growth, division, and development, since it is considered to be along with the pyrimidine base of the DNA helix. Since active protein synthesis is needed for the cell to enter the S phase and RNA synthesis is needed to prime new DNA synthesis, megaloblastic anaemia may be expected to occur only when DNA synthesis is inhibited but protein and RNA synthesis are relatively unimpaired
When the level becomes elevated or lower than the normal, the whole process will collapse because each process is linked to another. Serum folate reacts more rapidly to folate intake than erythrocyte folate. Our body needs folic acid for the synthesis, repair, and methylation of DNA. Countries have implemented either mandatory or voluntary food fortification of wheat flour and other grains, or else have no such program and depend on public health and healthcare practitioner advice to women of childbearing age.
They cannot be synthesized in sufficient amount by the human body, and therefore must be obtained from the diet. This defect is caused by thymidylate synthesis defective with deoxyuridine triphosphate enlargement. DNA replication is a discontinuous process and a number of enzymes are concerned with different aspects of the process. Also, the body does not have the ability to produce S-adenosyl methionine which is known as "SAM" product.
According to the spina bifida association, it can also lead to learning disabilities, gastrointestinal disorders, obesity, depression, urinary and bowel dysfunction, tendonitis, and allergies. Cytosine arabinoside, which also may cause megaloblastosis, may affect principally the synthesis of new DNA fragments. Some tissues are considered as glycine producers, while others, e. Definition[ edit ] "Folate" is the term used to name the many forms of the vitamin—namely folic acid and its congeners , including tetrahydrofolic acid the activated form of the vitamin , methyltetrahydrofolate the primary form found in the serum , methenyltetrahydrofolate, folinic acid, and folacin.
Thymidylate synthase It is an enzyme that plays a role in the replication of cells and tissues. Thymidylate synthase is involved in catalyzing the transfer of formaldehyde from folate to dUMP in order to form dTMP. It can be a result of vitamin B12 deficiency and also due to trapping folate, preventing it from doing its normal function.
Hyperhomocysteinemia is a medical condition that is characterized by an abnormally elevated level of homocysteine in the blood. Moreover, low serine level leads to decreased performance of the immune system since serine is involved in antibody formation. Vitamin B12 deficiency can also be involved in megaloblastic anemia and neural tube defects, as mentioned above in relation to folic acid.