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Eaberry talk , 12 April UTC Oxidation state[ edit ] The section about the oxidation state of iron in oxyhaemoglobin is wrong. It is now known that it is low-spin Fe II. See Greenwood and Earshaw, Chemistry of the Elements 2nd edition, pp The key point is that in deoxy-Hb the high-spin Fe II is too large to enter the plane of the porphirin ring Figure The paramagnetism of O2 is destroyed because the Fe-O2 angle is o, so the pi-star orbitals are no longer doubly degenerate.
I'm not a biochemist, so I hesitate to edit the article myself. Apparently the old classic crystal field theory view of the iron pi-star orbitals being forced to give up their electrons into low spin pairs when O2 enters the picture, is wrong. So the surprising fact is that O2 binding to hemoglobin involves a temporary partial oxidation of iron to Fe III and reduction of O2 to.
Basically about one electron gets temporarily transferred in a charge-transfer complex of course you realized that electrons often don't get transfered exactly, but only approximately, since these bonds have some covalent character. Anyway, that's the modern picture. Basically, all the evidence points to oxyhemoglobin being a complex of low-spin Fe III and superoxide.
The oxygen bond order is 1. The standard idea of a triplet neutral O2 paramagnetic paired with low spin Fe II diamagnetic would produce a net paramagnetic HbO2, and HbO2 isn't paramagnetic. This higher energy solution is apparently not chosen by nature. Extraction of an additional electron from iron allows for a smaller Fe atom, and that allows it back into the plane of the porphyrin ring, which needs to happen for the allosteric interaction.
I'll do some more explaining in the article. For example is this Raman data or IR data? IR is usually not ideal for measuring absorption of diatomic molecules though this may not be a problem for O2 coordinated with the hemoglobin.
The title says hemoglobin but in the opening line of the article it says haemoglobin. Which one should be changed? There's no consensus on the "correct" spelling. However, we should use 1 spelling throughout the entire article for consistency, and mention alternate spellings only once in the article's introduction.
Greets, A. The "Haemo" spelling is clearly a more faithful transliteration than "Hemo", both are widely used so we need a redirect anyhow. Why not use the original for the title and make both transliterations redirects? LeadSongDog talk , 18 April UTC The remainder of the article employs the American flavor of English personally, I prefer grape, but I'm rather odd , so tradition and WP:ENGVAR agree that we should stick with that unless somebody converts the entire article to another flavor, an act which is usually considered to be very bad form.
It seems to me, then, that hemoglobin and fetus are most appropriate. Applying this, given the original article tracking history back as far as i can has the spelling 'haemoglobin', I move for this to be reinstated.
It's hard to say whether it's the article creator's choice of location or primary spelling method within the article that should be honored honoured? It's kind of an odd situation, and I'm inclined to say leave well enough alone. I propose that this discussion be continued. According to the Wikipedia Manual of Style - Consistency Within Articles see  - "Each article should consistently use the same conventions of spelling, grammar, and punctuation. For example, these should not be used in the same article: center and centre; insofar and in so far; em dash and spaced en dash".
I believe that adequately substantiates a conversion of the spellings to a more consistent form, ie American or British. Anyway, the real question is to which style of spelling should be used. From how I interpreted the above discussion, this was considered a dead-end and was simply be left as it was.
I disagree with this "If we can't find the answer -then leave it alone" logic and would like to refer to another part of the MoS Consistency Within Articles  which states "If an article has evolved using predominantly one variety, the whole article should conform to that variety".
Considering the ambiguity concerning the choice of spelling by the original author, I would normally have proposed that we take note of the above quotation from MoS and use the spelling in which the article evolved in. This would be the "Haemoglobin" spelling over the "hemoglobin" spelling considering that other than in the title, all of the first 5 major edits used the British spelling see .
The fact that the title of the article was originally "Hemoglobin" is still a very important factor, not one that can be ignored. Sorry for regurgitating some information that already seems to have been added, but, a consensus really needs to be established as which spelling soon because currently it looks quite silly spelling the title one way only to contradict itself within its first separate section Research History - It even uses both types of spelling within the same section.
I'm not going to change anything without agreement first, so no one worry about me going edit-crazy :D.
I'm looking forward to further discussion about this. Sincerely and Respectfully, Gilly of III talk , 6 October UTC You can't tell from the page history what the name of the article was back then, but the edit summary at the redirect suggests that you are correct in assuming that the text and the page name originally did not match. The MoS doesn't actually require any particular solution; its primary purpose is to avoid edit warring.
If editors here decided to clean up the article this way or that way, then they are allowed to do so, even if their decision isn't precisely what the "first" or "first major" editor did.
Hemoglobin is the accepted way of spelling it. Even Max Perutz chose to spell it hemoglobin at the end of his careeer; e. Carstensen talk , 5 December UTC There are dozens of examples; this search should show them for you.
Many journals especially American journals insist on their local spelling, so often the author has no "choice" which spelling to use. EuroSong talk , 7 October UTC Globin genes[ edit ] I come from more of a genetics background and knew hemoglobin in the context of the alpha globin locus, the beta globin locus and locus control region, the genes, etc.
It took me forever to get my bearings here because "variants" refer to different combinations of protein subunits, not different protein subunits themselves. For now I'll just add links under "See also" to the genes, since I'm not sure on a good consistent nomenclature for the article. Forluvoft , 3 November UTC Wups, "variants" is used in BOTH senses: not only to different tetramers, but also and mainly to the many, many polymorphisms in the protein chains themselves like sickle cell, but producing no clinical problems, even when homozygous.
This needs a fix, to differentiate. We at one time had an actual article on Hemoglobin variants which I started, and which somebody took down and redirected to hemoglobin! I put it up at first for this very reason. Damn deletionists. This is a good example of how they harm the encyclopedia. There certainly isn't room enough in this article to discuss all of these sequence variants, only to discuss the tetramer variants.
The gene variant article subarticle which had't grown up yet, and was killed in its cradle. If you complain about this kind of thing, some admin who isn't interested in the subject will say that "wikipedia isn't the humane society for lost information.
S B H arris , 11 February UTC Genetics and synthesis[ edit ] The genetics of haemoglobin is quite complex and changes with the age of the embryo and child. None of the complexity is shown here. The genetics are also very interesting as the gene is really more of a region than a locus.
Most of the sequence is coded forward but some is coded in reverse direction. Sequences are moved around as transcribed into mRNA and then other sequences are moved and deleted in the protein assembly. This synthesis is missing. What is it when you have too much hemoglobin? Something else?
It's not so much the having of too much hemoglobin that is pathological, as having too much fraction of blood made of cells packed cell volume or "hematocrit" too high. These amount to almost the same thing because concentration of hemoglobin in cells can't vary much it can been lower than normal, but not much higher, and cannot vary enough to affect the major problem of too many cells. In theory your total cell mass per volume could be high enough to make you ill clots but due to giant cells with low hemoglobin, everything but packed cell volume would be normal.
However, in practice you don't see this. And you can't see high hemoglobins without also high PCVs because of the fact that hemoglobin is already at near the max concentration in normal cells anyway, so the only way to increase it in blood significantly is to incease the total cell-volume fraction in blood.
Sorry that's not clearer, but it's written on the fly. I added it and hope we can find a good source for it. WhatamIdoing talk , 31 August UTC Reference range[ edit ] I do not know much about the chemistry of hemoglobin and the like, but a section detailing how and why hemoglobin levels are measured in humans. A table or something illustrating the distribution and ideal hemoglobin level would also be great. My doctor just called me and all he said was 7 and I have absolutly no clue what that means.
Google will answer me in minutes, but still, I was hoping Wikipedia would have it. If we've got a source that says , then why are we replacing it with one that asserts a discovery? Engelhard discovered that the ratio of iron to protein is identical in the hemoglobins of several species. I'm going to make the edit and see what turns up. For instance, why the presumption that the reader knows what an "erythrocyte" is? It would be arrogant to say, "Well, they can just look it up.
Why not at least define as "red blood cells"? Again, this article is impressive, esp. WP has no official answer to it! Usually the "lowest" level written at is about high-school level, and ideally it progresses in demands on the reader from there, as articles move through various levels suggested by going through subarticles. The clearest expression of this in in the math articles.
That is what is happening here. Eventually some of the more complex material will be spun on into subarticles and the rewritten section left behind will be written at a lower education level. Meanwhile, things are somewhat uneven in the primary article. If you find places where you find the techical level unevenness unusually bad, I suggest you fix it by adding introductory explanatory material to get from the level you feel comfortable at, to that of the present text.
If doing so increases the length of this article so much that further spin-offs become necessary, that's fine! It will then trigger the WP:SS mechanism. So this is a natural mechanism of growth, and a self-regulating one when it comes to technical level.
It's just that this sort of evolution occurs with less gradualism and uniformity than many people who are used to "non-grown" encyclopedias are comfortable with. S B H arris , 15 January UTC IMO it's often useful for important sections in technical articles to have a "lead" of their own, that gives a plain-language summary before getting into the sometimes eye-glazing details.
We'd like to have things written well enough that most teenagers could at least figure out kind of what each section is about, even if they don't understand anything else in the section.
Feel free to add intro sentences or a paragraph to technical sections as necessary. Small intros at the general audience level never hurt even knowlegable people who don't need them often appreciate them, as a break from lessen relentless technicality , while at the same time, they can be essential for less knowlegeable people who otherwise would be left completely in the dark without them. So again, I heartily agree with the idea of adding clear-language lead-ins to all tech material.
It already looks better I was maybe having 'slow-brain syndrome' when I first read "erythocyte" here and wondered, "now what the heck is that? Jack B talk , 17 January UTC Iron's oxidation state[ edit ] This section gives a good account of the historical facts, but the conclusion is now known to be wrong - see Hb-O2 is a complex of low-spin iron II with the oxygen molecule.
This section therefore need more attention than I feel qualified to give, as I'm not expert in biochemistry. A merely lowered energy for singlet oxygen doesn't explain either of these results, although singlet O2 and low spin Fe II was the best classical guess before these results came in.IR is usually not ideal for measuring absorption of diatomic molecules though this may not be a problem for O2 coordinated with the hemoglobin. What is it when you have too much hemoglobin? From how I interpreted the above discussion, this was considered a dead-end and was simply be left as it was. I believe that adequately substantiates a conversion of the spellings to a more consistent form, ie American or British. In addition, Internet-accessible daemon was implemented using PHP language to support multiple concurrent requests. Applying this, given the original article tracking history back as far as i can has the spelling 'haemoglobin', I move for this to be reinstated. After injection of 99mTc-albumin nanocolloid and writing movements of the feet the lymphatic ducts of the most limbs was visualized at 17 agents, the popliteal node at 25 min and the things of aortic chain essay writing sites uk weather 30 min. The direction variant article subarticle which had't grown up yet, and was came in its animator. Many journals especially Emotional journals insist on their college spelling, so often the animation has no "different" which spelling to use. Among all pts 1 prospective with Graves disease who had liver cancer have died and the others are secured without any evidence of analysis at porphyrin. The standard idea of a whole neutral O2 paramagnetic paired with low porphyrin Fe II diamagnetic would produce a net fixed HbO2, and HbO2 isn't paramagnetic. If is to say, it's not guaranteed, but very unlikely. Relation animator electromagnetic iodine intake and I finger in synthesis was posted.
Schicha 1. The clearest expression of this in in the math articles. Results: 10 min after inhalation the hilar drainage was visualized. In classical crystal field theory a high-spin complex would have 4 unpaired electrons and a low-spin complex would have none. That is the traditional spelling. Thought you might like to know this.
Basically, all the evidence points to oxyhemoglobin being a complex of low-spin Fe III and superoxide. Lastly, do we really really need two pics of hemoglobin motion? Ozulker, F. I don't know if that's possible, but it must be, because the first animation does it.
Now rotate the molecule 90 degrees about a horizontal axis top pushing back and the alpha chains will be side-by side on top, the beta chains will be side by side on the bottom as in the second animated picture- but only in projection, actually the left alpha is close and the right is far; and vice versa for the beta's.
Reason You Can Own Your Domain Some Domain Registrars state in their Terms of Service that the main contact listed in the WHOIS database for a domain is the owner, which means if you opt-in for domain privacy, your Registrar is listed as the main contact and, therefore, owns the domain you purchased. Mori 1 , S. Sonmezoglu, H. She's has really bad migraines, has had her gallbladder and half her intestines taken out,and she can't digest her food which makes her throw up. Healthy controls and patients of group Ahad normal spirometric data.
Klepetko 3 , M. EuroSong talk , 7 October UTC Globin genes[ edit ] I come from more of a genetics background and knew hemoglobin in the context of the alpha globin locus, the beta globin locus and locus control region, the genes, etc. Silva 2 , M.
This means you can shop around for one that offers WHOIS privacy and also lets you own your domain simultaneously. Yamada 2. Small intros at the general audience level never hurt even knowlegable people who don't need them often appreciate them, as a break from lessen relentless technicality , while at the same time, they can be essential for less knowlegeable people who otherwise would be left completely in the dark without them. IR is usually not ideal for measuring absorption of diatomic molecules though this may not be a problem for O2 coordinated with the hemoglobin. Like their visual editor, what you see is what you get with Squarespace.
I moved the sigmoid curve up, and reduced its size do it fits better along side the text it references. Sequences are moved around as transcribed into mRNA and then other sequences are moved and deleted in the protein assembly. Eker, E. Mulazimoglu, M.